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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304664
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc39a6
Name: solute carrier family 39 member 6
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc39a6decreases expressionISOSLC39A6 (Homo sapiens)6480464CTDtrichostatin A results in decreased expression of SLC39A6 mRNAPMID:24935251 PMID:26272509
Slc39a6decreases response to substanceISOSLC39A6 (Homo sapiens)6480464CTDSLC39A6 mutant form results in decreased susceptibility to trichostatin APMID:19887557
Slc39a6increases expressionISOSLC39A6 (Homo sapiens)6480464CTDtrichostatin A results in increased expression of SLC39A6 mRNA; trichostatin A results in increased expression of SLC39A6 proteinPMID:19887557
Slc39a6multiple interactionsISOSLC39A6 (Homo sapiens)6480464CTD[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC39A6 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form results in decreased susceptibility to trichostatin A]; SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]; SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]; SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]; SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form results in decreased susceptibility to trichostatin A]]PMID:19887557 PMID:27188386
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