GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304659
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arhgef2
Name: Rho/Rac guanine nucleotide exchange factor 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13122266480464CTDLipopolysaccharides results in increased expression of ARHGEF2 protein

PMID:22226621
multiple interactionsISORGD:13122266480464CTDARHGEF2 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]

ARHGEF2 mutant form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]

ARHGEF2 mutant form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]

ARHGEF2 mutant form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]

ARHGEF2 mutant form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

Lipopolysaccharides promotes the reaction [TLR4 protein binds to ARHGEF2 protein]

TLR4 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of ARHGEF2 protein]

PMID:22226621
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.