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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304603
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nrf1
Name: nuclear respiratory factor 1
Acc ID: CHEBI:17158
Term: methylglyoxal
Definition: A 2-oxo aldehyde derived from propanal.
Chemical ID: MESH:D011765
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nrf1increases expressionEXP 6480464CTDPyruvaldehyde results in increased expression of NRF1 mRNAPMID:23331247
Nrf1multiple interactionsEXP 6480464CTDmonascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]; Silymarin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]; Tretinoin inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]]PMID:23331247
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