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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt3b
Name: DNA methyltransferase 3 beta
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt3bdecreases expressionISODNMT3B (Homo sapiens)6480464CTDsulforaphane results in decreased expression of DNMT3B mRNAPMID:24466240
Dnmt3bmultiple interactionsISODNMT3B (Homo sapiens)6480464CTDsulforaphane inhibits the reaction [DNMT3B protein binds to COMT promoter]; sulforaphane inhibits the reaction [Estradiol promotes the reaction [DNMT3B protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Estradiol results in increased expression of DNMT3B mRNA]PMID:30684530
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