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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt3b
Name: DNA methyltransferase 3 beta
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt3bdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of DNMT3B mRNAPMID:25181051 PMID:25748669
Dnmt3bincreases expressionEXP 6480464CTDbisphenol A results in increased expression of DNMT3B mRNA; bisphenol A results in increased expression of DNMT3B proteinPMID:21827818 PMID:22109888 PMID:23748860 PMID:26898831
Dnmt3bincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of DNMT3B genePMID:28505145
Dnmt3bmultiple interactionsEXP 6480464CTD[Testosterone co-treated with Estradiol] affects the reaction [bisphenol A results in increased expression of DNMT3B mRNA]PMID:22109888
Dnmt3baffects methylationISODnmt3b (Mus musculus)6480464CTDbisphenol A affects the methylation of DNMT3B promoterPMID:27334623
Dnmt3bdecreases expressionISODnmt3b (Mus musculus)6480464CTDbisphenol A results in decreased expression of DNMT3B mRNA; bisphenol A results in decreased expression of DNMT3B proteinPMID:22131059 PMID:23418087 PMID:27502578 PMID:30951980 PMID:31201698
Dnmt3bdecreases expressionISODNMT3B (Homo sapiens)6480464CTDbisphenol A results in decreased expression of DNMT3B proteinPMID:37567409
Dnmt3bdecreases methylationISODNMT3B (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of DNMT3B promoterPMID:27271280
Dnmt3bincreases expressionISODnmt3b (Mus musculus)6480464CTDbisphenol A results in increased expression of DNMT3B mRNA; bisphenol A results in increased expression of DNMT3B proteinPMID:23535407 PMID:30892605 PMID:31532523 PMID:32488702
Dnmt3bincreases expressionISODNMT3B (Homo sapiens)6480464CTDbisphenol A results in increased expression of DNMT3B mRNA; bisphenol A results in increased expression of DNMT3B proteinPMID:27685785 PMID:32030086 PMID:32105160 PMID:34537452
Dnmt3bmultiple interactionsISODnmt3b (Mus musculus)6480464CTDDrugs, Chinese Herbal inhibits the reaction [bisphenol A results in increased expression of DNMT3B protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT3B mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of DNMT3B mRNA]PMID:22131059 PMID:30892605 PMID:32488702
Dnmt3bmultiple interactionsISODNMT3B (Homo sapiens)6480464CTDbisphenol A promotes the reaction [ESR1 protein binds to DNMT3B promoter]; ESR1 protein promotes the reaction [bisphenol A results in increased expression of DNMT3B mRNA]; ESR1 protein promotes the reaction [bisphenol A results in increased expression of DNMT3B protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of DNMT3B protein]PMID:32105160 PMID:34537452
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