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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt3b
Name: DNA methyltransferase 3 beta
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt3bdecreases expressionISODnmt3b (Mus musculus)6480464CTDCurcumin analog results in decreased expression of DNMT3B proteinPMID:26991801 PMID:29228771
Dnmt3bdecreases expressionISODNMT3B (Homo sapiens)6480464CTDCurcumin results in decreased expression of DNMT3B mRNAPMID:23593078
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