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GENE - TERM ANNOTATION REPORT

RGD ID: 1303134
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abca7
Name: ATP binding cassette subfamily A member 7
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alzheimer%27s_disease "DO" "DO", http://www.merriam-webster.com/medical/alzheimer%27s%20disease "DO" "DO", http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abca7 ISOABCA7 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:21460840 PMID:25807283
Abca7 ISOABCA7 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Alzheimer disease, early onsetPMID:25741868 PMID:25807283 PMID:26141617 PMID:27066581 PMID:28492532
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