Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303073
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1affects localizationEXP 6480464CTDThapsigargin affects the localization of XBP1 proteinPMID:16338971
Xbp1increases splicingEXP 6480464CTDThapsigargin results in increased splicing of XBP1 mRNAPMID:18477628 PMID:23123503 PMID:24638036
Xbp1affects splicingISOXBP1 (Homo sapiens)6480464CTDThapsigargin affects the splicing of XBP1 mRNAPMID:23885834
Xbp1decreases response to substanceISOXBP1 (Homo sapiens)6480464CTDXBP1 protein results in decreased susceptibility to ThapsigarginPMID:19135031
Xbp1increases activityISOXBP1 (Homo sapiens)6480464CTDThapsigargin results in increased activity of XBP1 proteinPMID:20816668 PMID:23383089
Xbp1increases cleavageISOXBP1 (Homo sapiens)6480464CTDThapsigargin results in increased cleavage of XBP1 mRNAPMID:19946333
Xbp1increases expressionISOXbp1 (Mus musculus)6480464CTDThapsigargin results in increased expression of XBP1 mRNA; Thapsigargin results in increased expression of XBP1 mRNA alternative form; Thapsigargin results in increased expression of XBP1 proteinPMID:20589738 PMID:22509299 PMID:23576437 PMID:32578922
Xbp1increases expressionISOXBP1 (Homo sapiens)6480464CTDThapsigargin results in increased expression of XBP1 mRNA; Thapsigargin results in increased expression of XBP1 mRNA alternative form; Thapsigargin results in increased expression of XBP1 protein; Thapsigargin results in increased expression of XBP1 protein alternative formPMID:17917237 PMID:18773883 PMID:22378314 PMID:23576437 PMID:23741617 PMID:25289770 PMID:27358234 PMID:27587023 PMID:29453283 PMID:30796460 PMID:32407927 PMID:35033536
Xbp1increases splicingISOXbp1 (Mus musculus)6480464CTDThapsigargin results in increased splicing of XBP1 mRNAPMID:25324550
Xbp1increases splicingISOXBP1 (Homo sapiens)6480464CTDThapsigargin results in increased splicing of XBP1 mRNAPMID:17353921 PMID:17917237 PMID:19428936 PMID:25164867 PMID:25324550 PMID:25616597 PMID:29126784 PMID:35033536
Xbp1multiple interactionsISOXbp1 (Mus musculus)6480464CTD1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA alternative form]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of XBP1 mRNA]; Thapsigargin inhibits the reaction [7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Palmitic Acid results in increased expression of XBP1 mRNA alternative form]]; XBP1 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of SIRT7 mRNA]; XBP1 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of SIRT7 protein]PMID:22509299 PMID:23576437 PMID:24210820 PMID:29414781 PMID:32578922
Xbp1multiple interactionsISOXBP1 (Homo sapiens)6480464CTD1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein]; BCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein alternative form]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA alternative form]; MKC9989 inhibits the reaction [Thapsigargin results in increased splicing of XBP1 mRNA]; mycotrienin II inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA]; trienomycin A inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA]; trierixin inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA]; trierixin inhibits the reaction [Thapsigargin results in increased splicing of XBP1 mRNA]; Tunicamycin inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA]PMID:17917237 PMID:23576437 PMID:23885834 PMID:25164867 PMID:32407927
Go Back to source page   Continue to Ontology report