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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303043
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Clic1
Name: chloride intracellular channel 1
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Clic1decreases response to substanceISOCLIC1 (Homo sapiens)6480464CTDCLIC1 protein results in decreased susceptibility to CarmustinePMID:18590702
Clic1multiple interactionsISOCLIC1 (Homo sapiens)6480464CTD[4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of CLIC1 protein] which results in increased susceptibility to CarmustinePMID:18590702
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