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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303001
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pofut1
Name: protein O-fucosyltransferase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pofut1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of POFUT1 mRNAPMID:25181051 PMID:30816183 PMID:32528016 PMID:34947998
Pofut1increases expressionEXP 6480464CTDbisphenol A results in increased expression of POFUT1 mRNAPMID:32145629
Pofut1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of POFUT1 genePMID:28505145
Pofut1increases expressionISOPOFUT1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of POFUT1 proteinPMID:33376534 PMID:34186270 PMID:37567409
Pofut1increases methylationISOPofut1 (Mus musculus)6480464CTDbisphenol A results in increased methylation of POFUT1 promoterPMID:27312807
Pofut1multiple interactionsISOPOFUT1 (Homo sapiens)6480464CTD[ginger extract results in increased abundance of Oils, Volatile] inhibits the reaction [bisphenol A results in increased expression of POFUT1 protein]PMID:33376534
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