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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1302993
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ly96
Name: lymphocyte antigen 96
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ly96affects bindingISOLY96 (Homo sapiens)6480464CTDLipopolysaccharides binds to [TLR4 protein binds to LY96 protein]; Lipopolysaccharides binds to LY96 proteinPMID:26037075 PMID:28063877
Ly96decreases response to substanceISOLY96 (Homo sapiens)6480464CTDLY96 exon mutant form results in decreased susceptibility to Lipopolysaccharides; LY96 protein mutant form results in decreased susceptibility to LipopolysaccharidesPMID:16367934
Ly96increases expressionISOLY96 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of LY96 mRNAPMID:26037075
Ly96increases response to substanceISOLy96 (Mus musculus)6480464CTDLY96 protein results in increased susceptibility to LipopolysaccharidesPMID:16367934
Ly96multiple interactionsISOLY96 (Homo sapiens)6480464CTD1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [Lipopolysaccharides binds to LY96 protein]; [LY96 protein results in increased expression of CD14 mRNA] which results in increased susceptibility to Lipopolysaccharides; [LY96 protein results in increased expression of TLR4 mRNA] which results in increased susceptibility to Lipopolysaccharides; LY96 protein promotes the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]; procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of LY96 mRNA]PMID:20700758 PMID:26037075 PMID:28063877
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