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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1302972
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ehmt2
Name: euchromatic histone lysine methyltransferase 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ehmt2affects expressionISOEhmt2 (Mus musculus)6480464CTDValproic Acid affects the expression of EHMT2 mRNAPMID:17963808
Ehmt2decreases expressionISOEHMT2 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of EHMT2 mRNAPMID:19101580 PMID:23179753 PMID:26272509 PMID:28001369
Ehmt2increases methylationISOEHMT2 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of EHMT2 genePMID:29154799
Ehmt2multiple interactionsISOEHMT2 (Homo sapiens)6480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of EHMT2 mRNA; [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EHMT2 mRNAPMID:17183730 PMID:27188386
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