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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1302972
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ehmt2
Name: euchromatic histone lysine methyltransferase 2
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ehmt2decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of EHMT2 mRNAPMID:30557709
Ehmt2decreases expressionISOEhmt2 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of EHMT2 mRNAPMID:28414027
Ehmt2increases expressionISOEHMT2 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of EHMT2 proteinPMID:27217333
Ehmt2multiple interactionsISOEhmt2 (Mus musculus)6480464CTDsodium arsenite promotes the reaction [EHMT2 protein binds to CDKN2A promoter]PMID:22733434
Ehmt2multiple interactionsISOEHMT2 (Homo sapiens)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with BIX 01294] results in decreased expression of EHMT2 mRNA; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with BIX 01294] results in decreased expression of EHMT2 protein; [EHMT2 protein co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of MPG mRNA; [EHMT2 protein co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of MPG protein; [EHMT2 protein co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of PARP1 mRNA; [EHMT2 protein co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of PARP1 protein; [EHMT2 protein co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of XRCC1 mRNA; [EHMT2 protein co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of XRCC1 protein; BRD4770 inhibits the reaction [sodium arsenite promotes the reaction [EHMT2 protein binds to PDK4 promoter]]; sodium arsenite inhibits the reaction [BRD4770 results in decreased expression of EHMT2 protein]; sodium arsenite promotes the reaction [EHMT2 protein binds to PDK4 promoter]PMID:27217333 PMID:33378118
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