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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1302965
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon3
Name: paraoxonase 3
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon3decreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of PON3 mRNA; Carbon Tetrachloride results in decreased expression of PON3 proteinPMID:25478064 PMID:31150632
Pon3multiple interactionsEXP 6480464CTDRutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 protein]; schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 mRNA]PMID:25478064 PMID:31150632
Pon3affects expressionISOPon3 (Mus musculus)6480464CTDCarbon Tetrachloride affects the expression of PON3 mRNAPMID:17484886
Pon3decreases response to substanceISOPON3 (Homo sapiens)6480464CTDPON3 protein results in decreased susceptibility to Carbon TetrachloridePMID:20079818
Pon3multiple interactionsISOPON3 (Homo sapiens)6480464CTDPON3 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione]; PON3 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde]; PON3 protein inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL1B protein]; PON3 protein inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]PMID:20079818
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