GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CASP7 | increases activity | EXP | | 6480464 | CTD | Metformin results in increased activity of CASP7 protein | PMID:21388661 | CASP7 | multiple interactions | EXP | | 6480464 | CTD | Cisplatin promotes the reaction [Metformin results in increased activity of CASP7 protein]; Metformin inhibits the reaction [sunitinib results in increased cleavage of CASP7 protein] | PMID:21388661 PMID:21906609 | CASP7 | multiple interactions | ISO | Casp7 (Rattus norvegicus) | 6480464 | CTD | dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]] | PMID:30551545 | | ||||||||||||||||||||||
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