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GENE - TERM ANNOTATION REPORT

RGD ID: 12736431
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Akr1b1
Name: aldo-keto reductase family 1 member B
Acc ID: DOID:83
Term: cataract
Definition: A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision. (DO)
Definition Source(s): url:http://en.wikipedia.org/wiki/Cataract "DO", url:http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001996/ "DO", url:https://www.ncbi.nlm.nih.gov/pubmed/10414631 "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1b1 ISORGD:20929068941RGDassociated with Galactosemia

PMID:17444799, REF_RGD_ID:1626083
Akr1b1 ISORGD:7321789068941RGDhuman gene in mouse model

PMID:21329682, REF_RGD_ID:8548638
Akr1b1susceptibilityISORGD:7321789068941RGDassociated with Diabetes Mellitus, Type 2, DNA:promoter:repeat:g.(AC)n (human)

PMID:24360973, REF_RGD_ID:8548672
Akr1b1treatmentISORGD:20929068941RGD PMID:18452283, REF_RGD_ID:8548671
Akr1b1 ISORGD:7321789068941CTDCTD Direct Evidence: marker/mechanism

PMID:21329682, PMID:21376710, PMID:25541468, PMID:28137510
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.