Gene Term Annotation Report - Rat Genome Database

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GENE - TERM ANNOTATION REPORT

RGD ID:	12732007
Species:	Ictidomys tridecemlineatus
RGD Object:	Gene
Symbol:	Med12
Name:	mediator complex subunit 12

Acc ID:	GO:0016592
Term:	mediator complex
Definition:	A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
Definition Source(s):	PMID:11454195, PMID:16168358, PMID:17870225

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Med12	part_of	IEA	UniProtKB:A2AGH6 or UniProtKB:Q93074 or ensembl:ENSMUSP00000085260 or ensembl:ENSP00000363193	150520179	Ensembl		GO_REF:0000107
Med12	part_of	IEA	InterPro:IPR019035 or InterPro:IPR021989	150520179	InterPro		GO_REF:0000002

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