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GENE - TERM ANNOTATION REPORT

RGD ID: 12661197
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Grin2b
Name: glutamate ionotropic receptor NMDA type subunit 2B
Acc ID: GO:0017146
Term: NMDA selective glutamate receptor complex
Definition: An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD.
Definition Source(s): http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grin2b ISOGrin2b (Rattus norvegicus)9068941RGD PMID:1350383 PMID:16477151 REF_RGD_ID:1642190 REF_RGD_ID:727540
Grin2blocated_inISOGrin2b (Rattus norvegicus)9068941ComplexPortalPMID:24876489

PMID:24876489 REF_RGD_ID:13432263
Grin2bpart_ofIEAUniProtKB:Q13224 or ensembl:ENSP00000477455150520179Ensembl GO_REF:0000107
Grin2bpart_ofIEAPANTHER:PTHR18966:SF382150520179TreeGrafter GO_REF:0000118
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