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GENE - TERM ANNOTATION REPORT

RGD ID: 12620109
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Hcn4
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 4
Acc ID: DOID:0060224
Term: atrial fibrillation
Definition: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Definition Source(s): http://en.wikipedia.org/wiki/Atrial_fibrillation "DO", http://www.mayoclinic.org/diseases-conditions/atrial-fibrillation/basics/definition/con-20027014 "DO", http://www.nhlbi.nih.gov/health/health-topics/topics/af "DO", MESH:D001281
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hcn4 ISORGD:7371269068941CTDCTD Direct Evidence: marker/mechanism

PMID:22544366, PMID:30061737
Hcn4 ISORGD:128832729068941ClinVarClinVar Annotator: match by term: Atrial fibrillation

PMID:25741868, PMID:28492532
Hcn4 ISORGD:86912859068941ClinVarClinVar Annotator: match by term: Atrial fibrillation

PMID:23861362, PMID:25145518, PMID:25145519, PMID:25642760, PMID:25741868, PMID:26467025, PMID:27173043, PMID:27659478, PMID:28104484, PMID:28182231, PMID:28254189, PMID:28492532
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.