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GENE - TERM ANNOTATION REPORT

RGD ID: 12618531
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Psenen
Name: presenilin enhancer, gamma-secretase subunit
Acc ID: GO:0070765
Term: gamma-secretase complex
Definition: A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.
Definition Source(s): GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Psenenpart_ofIEAUniProtKB:Q9CQR7 or UniProtKB:Q9NZ42 or ensembl:ENSMUSP00000044682 or ensembl:ENSP00000468411150520179Ensembl GO_REF:0000107
Psenenpart_ofIEAPANTHER:PTN000418978150520179TreeGrafter GO_REF:0000118
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