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GENE - TERM ANNOTATION REPORT

RGD ID: 12613017
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: GO:0004420
Term: hydroxymethylglutaryl-CoA reductase (NADPH) activity
Definition: Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH.
Definition Source(s): PMID:29224355, RHEA:15989
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HmgcrenablesIEAUniProtKB:P04035 or UniProtKB:Q01237 or ensembl:ENSMUSP00000022176 or ensembl:ENSP00000287936150520179Ensembl GO_REF:0000107
HmgcrenablesIEAInterPro:IPR002202 or InterPro:IPR004554 or InterPro:IPR004816 or InterPro:IPR023074 or InterPro:IPR023076 or InterPro:IPR023282150520179InterPro GO_REF:0000002
HmgcrenablesIEARHEA:15989150520179RHEA GO_REF:0000116
HmgcrenablesIEAPANTHER:PTHR10572:SF24150520179TreeGrafter GO_REF:0000118
HmgcrenablesIEAEC:1.1.1.34150520179UniProt GO_REF:0000003
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