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RGD ID: 12549326
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Rab14
Name: RAB14, member RAS oncogene family
Acc ID: PW:0000159
Term: Rab family mediated signaling pathway
Definition: Rab family mediated signaling pathways are involved in the regulation of intracellular vesicle trafficking. More than 60 Rab members bind to specific effectors to regulate all aspects of vesicular trafficking - from formation and transport of vesicles, to tethering and fusion with target membranes. Of note is that cytoskeletal rearrangements such as actin remodeling, a process regulated by Rho family, have a role to play in vesicular trafficking.
Definition Source(s): GO:0032482, PMID:11152757, PMID:16882731, PMID:18171430
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rab14 ISORGD:7371049068941RGD PMID:17629673, PMID:18171431, PMID:18570632, REF_RGD_ID:2302395, REF_RGD_ID:2302397, REF_RGD_ID:2306494
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.