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GENE - TERM ANNOTATION REPORT

RGD ID: 12501281
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alzheimer%27s_disease "DO" "DO", http://www.merriam-webster.com/medical/alzheimer%27s%20disease "DO" "DO", http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gapdh ISOGapdh (Mus musculus)9068941RGDprotein:decreased activity:cerebral cortex, cerebellumPMID:17324518 REF_RGD_ID:13792614
Gapdh ISOGapdh (Rattus norvegicus)9068941RGDprotein:decreased activity:cerebral cortex, hippocampusPMID:17324518 REF_RGD_ID:13792614
Gapdh ISOGAPDH (Homo sapiens)9068941RGD PMID:28087189 REF_RGD_ID:13792604
Gapdh ISOGAPDH (Homo sapiens)9068941RGDDNA:SNPs, haplotypes: :rs740850, rs1060620 (human)PMID:18340469 REF_RGD_ID:13792612
Gapdh ISOGAPDH (Homo sapiens)9068941RGDprotein:increased S-glutathionylation, decreased activity:inferior parietal cortexPMID:17387692 REF_RGD_ID:13792613
GapdhonsetISOGAPDH (Homo sapiens)9068941RGDDNA:snps:5' utr, intron: (rs3741916, rs1060621) (human)PMID:15507493 REF_RGD_ID:1358618
GapdhsusceptibilityISOGAPDH (Homo sapiens)9068941RGDDNA:SNP:5' utr:rs3741916 (human)PMID:20864222 REF_RGD_ID:13792611
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