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GENE - TERM ANNOTATION REPORT

RGD ID: 12488958
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Tgfb3
Name: transforming growth factor beta 3
Acc ID: DOID:9743
Term: diabetic neuropathy
Definition: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
Definition Source(s): MESH:D003929
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb3 ISOTgfb3 (Rattus norvegicus)9068941RGDassociated with Diabetes Mellitus, Experimental;mRNA:increased expression:sciatic nervePMID:18406405 REF_RGD_ID:2302086
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