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GENE - TERM ANNOTATION REPORT

RGD ID: 12486175
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Bdnf
Name: brain derived neurotrophic factor
Acc ID: DOID:9002955
Term: Nerve Degeneration
Definition: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Definition Source(s): MESH:D009410
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnf ISOBdnf (Rattus norvegicus)9068941RGD PMID:18313855 REF_RGD_ID:10059347
Bdnf ISOBDNF (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanism|therapeuticPMID:15372491 PMID:19457078 PMID:19686240 PMID:8921280 PMID:8978711
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