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GENE - TERM ANNOTATION REPORT

RGD ID: 12468236
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: DOID:7148
Term: rheumatoid arthritis
Definition: An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Rheumatoid_arthritis "DO" "DO", http://www.mayoclinic.org/diseases-conditions/rheumatoid-arthritis/home/ovc-20197388 "DO" "DO", http://www.nlm.nih.gov/medlineplus/ency/article/000431.htm "DO" "DO", http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=rheumatoid%20arthritis "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnf ISOTNF (Homo sapiens)9068941RGDmRNA:increased expression:synovial (human)PMID:22660635 REF_RGD_ID:155663483
Tnfno_associationISOTNF (Homo sapiens)9068941RGDDNA:SNP:promoter:-238G>A, -308G>A (human)PMID:25311255 REF_RGD_ID:12904065
TnftreatmentISOTNF (Homo sapiens)9068941RGD PMID:12563673 REF_RGD_ID:10450537
TnftreatmentISOTNF (Homo sapiens)9068941RGDDNA:SNP:promoter:-857C>T (human)PMID:25311255 REF_RGD_ID:12904065
Tnf ISOTNF (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanism|therapeuticPMID:12566094 PMID:2001072 PMID:22450443 PMID:34459104 PMID:8391952
Tnf ISOTnf (Mus musculus)9068941MouseDOOMIM:180300 
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