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GENE - TERM ANNOTATION REPORT

RGD ID: 12465841
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Grk2
Name: G protein-coupled receptor kinase 2
Acc ID: DOID:6000
Term: congestive heart failure
Definition: A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Heart_disease "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grk2 ISOGrk2 (Mus musculus)9068941RGD PMID:11331748 REF_RGD_ID:737776
Grk2 ISOGrk2 (Rattus norvegicus)9068941RGDassociated with Hypertrophy, Left Ventricular and Hypertension;protein:increased expression, increased activity:heart left ventricle, cytosol (rat)PMID:9931137 REF_RGD_ID:1625790
Grk2 ISOGRK2 (Homo sapiens)9068941RGDmRNA:decreased expression:peripheral blood mononuclear cell (human)PMID:26248277 REF_RGD_ID:11535540
Grk2treatmentISOGrk2 (Rattus norvegicus)9068941RGD PMID:29247373 REF_RGD_ID:13506830
Grk2 ISOGRK2 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:26670611
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