Gene Term Annotation Report - Rat Genome Database

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GENE - TERM ANNOTATION REPORT

RGD ID:	12463385
Species:	Ictidomys tridecemlineatus
RGD Object:	Gene
Symbol:	Rapgef4
Name:	Rap guanine nucleotide exchange factor 4

Acc ID:	GO:0007189
Term:	adenylate cyclase-activating G protein-coupled receptor signaling pathway
Definition:	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling.
Definition Source(s):	GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Rapgef4	involved_in	IEA	UniProtKB:Q9EQZ6 or ensembl:ENSMUSP00000088336	150520179	Ensembl		GO_REF:0000107
Rapgef4	acts_upstream_of_or_within	ISO	Rapgef4 (Mus musculus)	9068941	MGI	PMID:11598134 PMID:12401793	PMID:11598134 PMID:12401793

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