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GENE - TERM ANNOTATION REPORT

RGD ID: 12402167
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: PLG
Name: plasminogen
Acc ID: DOID:0111592
Term: plasminogen deficiency type I
Definition: A syndrome characterized by decreased serum plasminogen activity, decreased plasminogen antigen levels, and chronic mucosal pseudomembranous lesions typically manifesting as ligneous conjunctivitis that has_material_basis_in homozygous or compound heterozygous mutation in PLG on chromosome 6q26. (DO)
Definition Source(s): https://ghr.nlm.nih.gov/condition/congenital-plasminogen-deficiency "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/12850227 "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/16849641 "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/9242524 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLG ISOPLG (Homo sapiens)7240710OMIM  
PLG ISOPLG (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Dysplasminogenemia | ClinVar Annotator: match by term: Plasminogen deficiency, type IPMID:10233898 PMID:12850227 PMID:12876630 PMID:12945885 PMID:1427790 PMID:15269832 PMID:16849641 PMID:17576681 PMID:1986355 PMID:20981092 PMID:22995991 PMID:23629776 PMID:24029428 PMID:25741868 PMID:26340456 PMID:27976734 PMID:28492532 PMID:30487145 PMID:31064749 PMID:31589614 PMID:31980526 PMID:34355501 PMID:6216475 PMID:6238949 PMID:659588 PMID:8392398 PMID:9242524 PMID:9375744 PMID:9536098 PMID:9834305 PMID:9858247
PLG IAGP 12801476OMIALigneous membranitisPMID:8875361 PMID:18312178 PMID:9604341 PMID:27152037 PMID:26840763 PMID:26360520 PMID:23898908 PMID:22890402 PMID:19604341 PMID:34370320
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