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GENE - TERM ANNOTATION REPORT

RGD ID: 12398976
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: SDHAF2
Name: succinate dehydrogenase complex assembly factor 2
Acc ID: DOID:9007071
Term: Hereditary Neoplastic Syndromes
Definition: The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.
Definition Source(s): MESH:D009386
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SDHAF2 ISOSDHAF2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary Cancer Syndrome | ClinVar Annotator: match by term: Hereditary cancer | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromePMID:17576681 PMID:19628817 PMID:20071235 PMID:21348866 PMID:22241717 PMID:22703879 PMID:23062074 PMID:23666964 PMID:24033266 PMID:24414418 PMID:25741868 PMID:26016412 PMID:26096992 PMID:26467025 PMID:28099933 PMID:28492532 PMID:30050099 PMID:31687641 PMID:6286462 PMID:9536098
SDHAF2 ISOSDHAF2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary Cancer Syndrome | ClinVar Annotator: match by term: Hereditary cancer | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar Annotator: match by term: Hereditary neoplastic syndrome | ClinVar Annotator: match by term: Neoplastic Syndromes, HereditaryPMID:17576681 PMID:19628817 PMID:20071235 PMID:21224366 PMID:21348866 PMID:21752896 PMID:22241717 PMID:22703879 PMID:23062074 PMID:23666964 PMID:24033266 PMID:24414418 PMID:24712571 PMID:25394176 PMID:25741868 PMID:26016412 PMID:26096992 PMID:26269449 PMID:26467025 PMID:27600092 PMID:28099933 PMID:28492532 PMID:28892078 PMID:29641532 PMID:30050099 PMID:30306255 PMID:31687641 PMID:32741965 PMID:32830346 PMID:32887801 PMID:33748650 PMID:35668420 PMID:36597280 PMID:6264239 PMID:6286462 PMID:9536098
SDHAF2 ISOSDHAF2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary Cancer Syndrome | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromePMID:16199547 PMID:17576681 PMID:19628817 PMID:20071235 PMID:21224366 PMID:21348866 PMID:21752896 PMID:22241717 PMID:22703879 PMID:23062074 PMID:23666964 PMID:24033266 PMID:24414418 PMID:24712571 PMID:25394176 PMID:25741868 PMID:26016412 PMID:26096992 PMID:26269449 PMID:26467025 PMID:28099933 PMID:28492532 PMID:29641532 PMID:30050099 PMID:30306255 PMID:31687641 PMID:32741965 PMID:32887801 PMID:33748650 PMID:36597280 PMID:6264239 PMID:6286462 PMID:9536098
SDHAF2 ISOSDHAF2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary Cancer Syndrome | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar Annotator: match by term: Hereditary neoplastic syndromePMID:16199547 PMID:17576681 PMID:19628817 PMID:20071235 PMID:21224366 PMID:21348866 PMID:21752896 PMID:22241717 PMID:22703879 PMID:23062074 PMID:23666964 PMID:24033266 PMID:24414418 PMID:24712571 PMID:25394176 PMID:25741868 PMID:26016412 PMID:26096992 PMID:26269449 PMID:26467025 PMID:27600092 PMID:28099933 PMID:28492532 PMID:28892078 PMID:29641532 PMID:30050099 PMID:30306255 PMID:31687641 PMID:32741965 PMID:32830346 PMID:32887801 PMID:33748650 PMID:35668420 PMID:36597280 PMID:6264239 PMID:6286462 PMID:9536098
SDHAF2 ISOSDHAF2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary Cancer Syndrome | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar Annotator: match by term: Hereditary neoplastic syndrome | ClinVar Annotator: match by term: Neoplastic Syndromes, HereditaryPMID:17576681 PMID:19628817 PMID:20071235 PMID:21224366 PMID:21348866 PMID:22241717 PMID:22703879 PMID:23062074 PMID:23666964 PMID:24033266 PMID:24414418 PMID:24712571 PMID:25394176 PMID:25741868 PMID:26016412 PMID:26096992 PMID:26269449 PMID:26467025 PMID:27600092 PMID:28099933 PMID:28492532 PMID:28892078 PMID:29641532 PMID:30050099 PMID:30306255 PMID:31687641 PMID:32741965 PMID:32830346 PMID:32887801 PMID:33748650 PMID:35441217 PMID:35668420 PMID:36597280 PMID:36841802 PMID:6264239 PMID:6286462 PMID:9536098
SDHAF2 ISOSDHAF2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary Cancer Syndrome | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar Annotator: match by term: Neoplastic Syndromes, HereditaryPMID:17576681 PMID:19628817 PMID:20071235 PMID:20301715 PMID:21348866 PMID:22241717 PMID:22703879 PMID:23062074 PMID:23666964 PMID:24033266 PMID:24414418 PMID:25741868 PMID:26016412 PMID:26096992 PMID:26467025 PMID:28099933 PMID:28492532 PMID:30050099 PMID:31687641 PMID:6286462 PMID:9536098
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