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GENE - TERM ANNOTATION REPORT

RGD ID: 12383470
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: IL10
Name: interleukin 10
Acc ID: DOID:13241
Term: Behcet's disease
Definition: A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Beh%C3%A7et%27s_disease "DO" "DO", http://www.nlm.nih.gov/medlineplus/behcetssyndrome.html "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL10 ISOIL10 (Homo sapiens)9068941RGDDNA, protein:hypermethylation, decreased expression:promoter, serumPMID:29719061 REF_RGD_ID:14975149
IL10disease_progressionISOIL10 (Homo sapiens)9068941RGD PMID:15980236 REF_RGD_ID:1598628
IL10onsetISOIL10 (Homo sapiens)9068941RGD PMID:26654556 REF_RGD_ID:14975256
IL10susceptibilityISOIL10 (Homo sapiens)9068941RGDDNA:SNP:promoter:-592A>C (rs1800872) (human)PMID:29294320 REF_RGD_ID:14975131
IL10treatmentISOIl10 (Mus musculus)9068941RGD PMID:21506890 REF_RGD_ID:7364843
IL10 ISOIL10 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:20622878 PMID:20622879
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