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GENE - TERM ANNOTATION REPORT

RGD ID: 12368635
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: PTH
Name: parathyroid hormone
Acc ID: DOID:12466
Term: secondary hyperparathyroidism
Definition: Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
Definition Source(s): MESH:D006962
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTH ISOPth (Rattus norvegicus)9068941RGDassociated with Kidney Failure, ChronicPMID:23499504 REF_RGD_ID:7242414
PTH ISOPth (Rattus norvegicus)9068941RGDassociated with UremiaPMID:21335517 REF_RGD_ID:5135046
PTH ISOPTH (Homo sapiens)9068941RGDassociated with Renal Insufficiency, Chronic; DNA:snp:exon:g.350C>A (rs6256) (human)PMID:12046039 REF_RGD_ID:7242750
PTH ISOPTH (Homo sapiens)9068941RGDassociated with Renal Insufficiency, Chronic; protein:increased expression:serum (human)PMID:23121374 REF_RGD_ID:7242728
PTHtreatmentISOPTH (Homo sapiens)9068941RGDassociated with Kidney Failure, ChronicPMID:23529273 REF_RGD_ID:7242411
PTH ISOPTH (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:21350317 PMID:22118402 PMID:22373954
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