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GENE - TERM ANNOTATION REPORT

RGD ID: 12347307
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: ACE2
Name: angiotensin converting enzyme 2
Acc ID: DOID:10763
Term: hypertension
Definition: An artery disease characterized by chronic elevated blood pressure in the arteries. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Hypertension "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/24352797 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACE2 ISOACE2 (Homo sapiens)9068941RGDDNA:SNP:intron:8790A>G, associated with Metabolic Syndrome X (MeSH:D024821)PMID:16459167 REF_RGD_ID:1642828
ACE2 ISOAce2 (Rattus norvegicus)9068941RGDmRNA, protein:decreased expression:aortaPMID:20854846 REF_RGD_ID:9685442
ACE2 ISOAce2 (Rattus norvegicus)9068941RGDmRNA, protein:decreased expression:kidney (rat)PMID:12075344 REF_RGD_ID:629626
ACE2treatmentISOAce2 (Mus musculus)9068941RGD PMID:16788004 REF_RGD_ID:9685435
ACE2treatmentISOAce2 (Rattus norvegicus)9068941RGD PMID:17345786 REF_RGD_ID:9685433
ACE2 ISOACE2 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanism|therapeuticPMID:12075344 PMID:15833808 PMID:17473847 PMID:18391097 PMID:19221212 PMID:20559404 PMID:21859683
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