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GENE - TERM ANNOTATION REPORT

RGD ID: 12336288
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: ASTL
Name: astacin like metalloendopeptidase
Acc ID: GO:0004222
Term: metalloendopeptidase activity
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Definition Source(s): GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ASTLenablesIBAFB:FBgn0003719 or FB:FBgn0004885 or MGI:88176 or PANTHER:PTN000013301 or Mep1b (Rattus norvegicus) or WB:WBGene00003553 or ZFIN:ZDB-GENE-030131-2100150520179GO_Central GO_REF:0000033
ASTLenablesIEAInterPro:IPR001506150520179InterPro GO_REF:0000002
ASTLenablesIEAUniRule:UR000120488 or UniRule:UR000919020150520179UniProt GO_REF:0000104
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