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GENE - TERM ANNOTATION REPORT

RGD ID: 12328669
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: PTGS1
Name: prostaglandin-endoperoxide synthase 1
Acc ID: DOID:9000998
Term: Brain Injuries
Definition: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Definition Source(s): MESH:D001930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS1 ISOPtgs1 (Mus musculus)9068941RGD PMID:19719848 REF_RGD_ID:5688162
PTGS1 ISOPtgs1 (Rattus norvegicus)9068941RGDprotein:increased expression:microglia, macrophagePMID:11565600 REF_RGD_ID:5688242
PTGS1 ISOPTGS1 (Homo sapiens)9068941RGDprotein:increased expression:microglial cells, macrophage, endothelial cellPMID:12005397 REF_RGD_ID:5688239
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