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GENE - TERM ANNOTATION REPORT

RGD ID: 12322578
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: F2
Name: coagulation factor II, thrombin
Acc ID: DOID:684
Term: hepatocellular carcinoma
Definition: A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. (DO)
Definition Source(s): http://cancergenome.nih.gov/cancersselected/LiverHepatocellularCarcinoma "DO" "DO", http://en.wikipedia.org/wiki/Hepatocellular_carcinoma "DO" "DO", http://www.omim.org/entry/114550 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2severityISOF2 (Homo sapiens)9068941RGDassociated with liver cirrhosis;protein:altered expression, altered processing:liver (human)PMID:7620113 REF_RGD_ID:14975114
F2 ISOF2 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:2821104
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