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GENE - TERM ANNOTATION REPORT

RGD ID: 12322578
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: F2
Name: coagulation factor II, thrombin
Acc ID: DOID:11247
Term: disseminated intravascular coagulation
Definition: A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.
Definition Source(s): MESH:D004211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2 ISOF2 (Homo sapiens)9068941RGD PMID:1336986 REF_RGD_ID:10449429
F2 ISOF2 (Homo sapiens)9068941RGDassociated with Wounds and InjuriesPMID:19682336 REF_RGD_ID:10449422
F2 ISOF2 (Rattus norvegicus)9068941RGD PMID:22229668 PMID:23737601 REF_RGD_ID:10449432 REF_RGD_ID:6893489
F2 ISOF2 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:1894189
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