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GENE - TERM ANNOTATION REPORT

RGD ID: 12314459
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: IFNG
Name: interferon gamma
Acc ID: DOID:9146
Term: visceral leishmaniasis
Definition: A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Visceral_leishmaniasis "DO" "DO", http://www.dpd.cdc.gov/dpdx/HTML/Leishmaniasis.htm "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IFNGtreatmentISOIfng (Mus musculus)9068941RGD PMID:27999013 PMID:3104456 REF_RGD_ID:40890273 REF_RGD_ID:8158041
IFNG ISOIFNG (Homo sapiens)9068941CTDCTD Direct Evidence: therapeuticPMID:1901333 PMID:7854095
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