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GENE - TERM ANNOTATION REPORT

RGD ID: 12296192
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: FTO
Name: FTO alpha-ketoglutarate dependent dioxygenase
Acc ID: DOID:9970
Term: obesity
Definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Obesity "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FTO ISOFto (Rattus norvegicus)9068941RGDmRNA, protein:increased expression:liverPMID:35945320 REF_RGD_ID:329951016
FTO ISOFto (Rattus norvegicus)9068941RGDmRNA:increased expression:pancreasPMID:32420297 REF_RGD_ID:329951013
FTO ISOFTO (Homo sapiens)9068941RGDDNA:SNP: :rs9939609 (human)PMID:23111453 REF_RGD_ID:329812010
FTO ISOFTO (Homo sapiens)9068941RGDDNA:SNP:intron:rs17817449 (human)PMID:21919686 REF_RGD_ID:329812040
FTO ISOFTO (Homo sapiens)9068941RGDDNA:SNP:intron:rs9939609 (human)PMID:23134754 REF_RGD_ID:329812007
FTO ISOFTO (Homo sapiens)9068941RGDDNA:SNPs: :rs9939609, rs1421085, rs17817449 (human) PMID:29540276 REF_RGD_ID:329845887
FTO ISOAPOA5 (Homo sapiens)9068941RGDDNA:SNP: :rs3751812 (human)PMID:25606423 REF_RGD_ID:329901774
FTOseverityISOFTO (Homo sapiens)9068941RGD PMID:31801409 REF_RGD_ID:329812016
FTO ISOFTO (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:17496892 PMID:19079260 PMID:19079261 PMID:19151714 PMID:19918250 PMID:21076408
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