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GENE - TERM ANNOTATION REPORT

RGD ID: 12264445
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: INSIG1
Name: insulin induced gene 1
Acc ID: GO:0032933
Term: SREBP signaling pathway
Definition: The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
Definition Source(s): GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
INSIG1involved_inIEAUniProtKB:O15503 or ensembl:ENSP00000344741150520179Ensembl GO_REF:0000107
INSIG1involved_inIEAPANTHER:PTHR15301:SF11150520179TreeGrafter GO_REF:0000118
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