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GENE - TERM ANNOTATION REPORT

RGD ID: 12260125
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: CASP8
Name: caspase 8
Acc ID: GO:0097153
Term: cysteine-type endopeptidase activity involved in apoptotic process
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process.
Definition Source(s): GOC:mtg_apoptosis
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP8enablesIEAUniProtKB:Q14790 or ensembl:ENSP00000501268150520179Ensembl GO_REF:0000107
CASP8enablesISSUniProtKB:Q14790150520179UniProt GO_REF:0000024
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