Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - TERM ANNOTATION REPORT

RGD ID: 12260125
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: CASP8
Name: caspase 8
Acc ID: GO:0060546
Term: negative regulation of necroptotic process
Definition: Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
Definition Source(s): GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP8involved_inIEAUniProtKB:Q14790 or ensembl:ENSP00000501268150520179Ensembl GO_REF:0000107
CASP8acts_upstream_of_or_withinISOMGI:1047989068941MGI PMID:22089168

PMID:22089168
CASP8acts_upstream_of_or_withinISOMGI:104798 or MGI:1336166 or MGI:21549529068941MGI PMID:21368763

PMID:21368763
CASP8acts_upstream_of_or_withinISOMGI:104798 or MGI:19215069068941MGI PMID:22037414

PMID:22037414
CASP8acts_upstream_of_or_withinISOMGI:21549529068941MGI PMID:21402742

PMID:21402742
Go Back to source page   Continue to Ontology report