Gene Term Annotation Report - Rat Genome Database

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GENE - TERM ANNOTATION REPORT

RGD ID:	12259272
Species:	Canis lupus familiaris
RGD Object:	Gene
Symbol:	EP300
Name:	E1A binding protein p300

Acc ID:	GO:0003713
Term:	transcription coactivator activity
Definition:	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
Definition Source(s):	GOC:txnOH-2018, PMID:10213677, PMID:16858867

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
EP300	enables	IEA	UniProtKB:B2RWS6 or UniProtKB:Q09472 or ensembl:ENSMUSP00000066789 or ensembl:ENSP00000263253	150520179	Ensembl		GO_REF:0000107
EP300	enables	IEA	InterPro:IPR014744	150520179	InterPro		GO_REF:0000002
EP300	enables	IEA	PANTHER:PTHR13808:SF29	150520179	TreeGrafter		GO_REF:0000118

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