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GENE - TERM ANNOTATION REPORT

RGD ID: 12258553
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: PLAU
Name: plasminogen activator, urokinase
Acc ID: DOID:9003676
Term: Brain Hypoxia-Ischemia
Definition: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
Definition Source(s): MESH:D020925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLAU ISOPlau (Rattus norvegicus)9068941RGD PMID:19587273 REF_RGD_ID:2316117
PLAU ISOPlau (Rattus norvegicus)9068941RGDmRNA, protein:increased expression, increased activity:hippocampus (rat)PMID:18467699 REF_RGD_ID:6483831
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