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GENE - TERM ANNOTATION REPORT

RGD ID: 12257048
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: NKX2-5
Name: NK2 homeobox 5
Acc ID: GO:0001947
Term: heart looping
Definition: The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
Definition Source(s): GOC:dph, PMID:12094232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NKX2-5acts_upstream_of_or_withinISOMGI:19272279068941MGI PMID:7628699 PMID:9192865

PMID:7628699 PMID:9192865
NKX2-5acts_upstream_of_or_withinISONkx2-5 (Mus musculus)9068941MGI PMID:16510504

PMID:16510504
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