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GENE - TERM ANNOTATION REPORT

RGD ID: 12245430
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: SREBF2
Name: sterol regulatory element binding transcription factor 2
Acc ID: PW:0000720
Term: altered p53 signaling pathway
Definition: A p53 signaling pathway that deviates from what its normal course should be. Due to its central role at the intersection of many cellular pathways, disturbance of p53 network can have far-reaching negative consequences. The tumor suppressor Tp53 gene is frequently mutated in cancer.
Definition Source(s): PMID:19776744
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SREBF2 ISOSREBF2 (Homo sapiens)9068941RGD PMID:22713868 PMID:23263379 REF_RGD_ID:8663430 REF_RGD_ID:8663431
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