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GENE - TERM ANNOTATION REPORT

RGD ID: 12243345
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: DOID:9007692
Term: Insulin Resistance
Definition: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
Definition Source(s): MESH:D007333
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3 ISONos3 (Rattus norvegicus)9068941RGDprotein:decreased expression:serumPMID:18298918 REF_RGD_ID:2292098
NOS3treatmentISONos3 (Rattus norvegicus)9068941RGD PMID:28946194 REF_RGD_ID:13450950
NOS3 ISONOS3 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanism|therapeuticPMID:11457755 PMID:12716763 PMID:12947532 PMID:19008412
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