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RGD ID: 12222994
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: CUL4A
Name: cullin 4A
Acc ID: GO:0031146
Term: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Definition: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
Definition Source(s): PMID:15380083
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBACGD:CAL0000174561, MGI:MGI:1349658, PANTHER:PTN000231993, PomBase:SPAC17G6.12, SGD:S000002290, UniProtKB:Q1361613508589GO_Central (PMID:21873635)

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.