Gene Term Annotation Report - Rat Genome Database

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GENE - TERM ANNOTATION REPORT

RGD ID:	12222778
Species:	Canis lupus familiaris
RGD Object:	Gene
Symbol:	DHX36
Name:	DEAH-box helicase 36

Acc ID:	GO:0051880
Term:	G-quadruplex DNA binding
Definition:	Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.
Definition Source(s):	PMID:16142245, PMID:9512530

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
DHX36	enables	IEA	UniProtKB:Q8VHK9 or UniProtKB:Q9H2U1 or ensembl:ENSMUSP00000029336 or ensembl:ENSP00000417078	150520179	Ensembl		GO_REF:0000107
DHX36	enables	IEA	PANTHER:PTHR18934:SF237	150520179	TreeGrafter		GO_REF:0000118

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