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GENE - TERM ANNOTATION REPORT

RGD ID: 12222722
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: DLA-DRB1
Name: MHC class II DLA DRB1 beta chain
Acc ID: DOID:437
Term: myasthenia gravis
Definition: An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath. (DO)
Definition Source(s): https://www.ninds.nih.gov/health-information/disorders/myasthenia-gravis "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DLA-DRB1onsetISOHLA-DRB1 (Homo sapiens)9068941RGDDNA:polymorphism: :HLA-DRB1*0901, HLA-DRB1*1302(human)PMID:15003812 REF_RGD_ID:7365079
DLA-DRB1susceptibilityISOHLA-DRB1 (Homo sapiens)9068941RGDDNA:polymorphism: :HLA-DRB1∗09,HLA- DRB1∗08(human)PMID:21924912 REF_RGD_ID:7365051
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